Eating saturated fats at certain times may “jet lag” internal body clocks, as well as the resulting inflammation, according to new research.
Circadian clocks, which exist in cells throughout the body, regulate the local timing of important cellular processes necessary for normal functioning and help keep inflammatory responses in check.
“When you disrupt that timing, the 24-hour organisation, there are consequences, and this is a contributing factor in many human health disorders, especially metabolic disease,” says David Earnest, professor at the Texas A&M College of Medicine’s department of neuroscience and experimental therapeutics.
In the short term, inflammation is considered to be a protective response to injury or invading bacteria, but the chronic, low-grade inflammation caused by high-fat diets contributes to obesity and type 2 diabetes and other inflammation-related disorders like cardiovascular disease, stroke, and rheumatoid arthritis.
Earnest compares this phenomenon to the confusion that would develop if the wall clock in your office was set to 2 p.m., the one on your computer indicated 4 p.m., and your wristwatch was showing 2:30 p.m., all while the clock on your cellphone reflected the accurate time of 1 p.m. CST. However, you might not know which one is correct, just as your body is confused when its various types of cells are reflecting different “clocks.”
Unfortunately, palmitate (also called palmitic acid) is one of the most commonly consumed long chain saturated fats in the Western diet.
Breakfast, not dinner
“Chronic inflammation is determined by what saturated fats you have in your diet and when you eat them,” Earnest says. The reported findings predict the best time to eat a high-fat meal is early in the morning and probably the worst time is late at night. So, it’s not just what you eat, but also when you eat it.
The latest findings also show that specific polyunsaturated “good” fats and other anti-inflammatory drugs had protective effects at times when saturated fats cause maximal inflammation and the resetting of body clocks.
“Not all fats are bad for you,” Earnest says. “We wanted to look specifically comparing palmitate with DHA, which is a common polyunsaturated omega 3.”
Consistent with established findings that DHA is anti-inflammatory, the results indicate that disrupting the inflammatory response with this omega 3 also blocked the resetting of body clocks to the wrong time. Thus, Earnest believes that chronotherapeutic strategies using omega 3 fatty acids or other anti-inflammatory treatments may be effective in preventing these local time changes in our body clocks caused by saturated fats.
